Endocrine Abstracts

Graves’ disease (GD) is an autoimmune disease caused by autoantibodies binding to and activating the thyroid-stimulating hormone receptor (TSHR). Chronic stimulation of the TSHR results in a hyperactive thyroid gland and hyperthyroidism. The purpose of this study was to determine the association between Rho-kinase (ROCK1 and ROCK2) gene polymorphisms and GD in a Turkish population. A total of 142 patients with HT and 163 healthy control subjects were in...

Graves’ disease (GD) is an organ-specific autoimmune disorder of the thyroid due to the presence of circulating anti-thyroid-stimulating-hormone receptor stimulating autoantibodies that lead to hyperthyroidism. Involvement of the genetic variants of RHO genes in GD has not been examined yet. Therefore, the aim of this study was to investigate possible associations between RHO gene polymorphisms and GD in a Turkish population. A total of 128 patients with GD and ...

Introduction: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, oligo-anovulation and/or polycystic ovary. Hypotheses such as genetic and environmental causes, disruption of the hypothalamo-pituitary-gonadal axis, insulin resistance, hyperinsulinemia and increased oxidative stress have been proposed to explain the etiopathogenesis of PCOS. In our study, we aimed to evaluate oxidative stress parameters and serum fetuin-A levels and to investigate their role...

Introduction: Acromegaly is a chronical and rare disease which is accompanied by excessive growth hormone (GH) secreting hypohysis tumor. In this study we presented acromegaly patients’ datas who admitted to our center between the years 1998–2016. We discussed patients’ charecteristics and we aimed to investigate the determinants which is effecting the remission rate of the patients’.Method: 70 acromegaly patients datas were analyzed ...

Introduction: Certain sensory system functions are affected somehow in acromegaly, however auditory complications have not been identified in detail yet. It is possible that widespread changes in acromegaly may also affect auditory system. We aimed to determine the changes involving auditory system in cases with acromegaly.Methods/design: Otological examination of 41 cases with acromegaly (active n=22, inactive n=19) were compared with ...

Introduction: Metabolic syndrome (MetS) is correlated with increased cardiovascular risk and characterized by several factors, including visceral obesity, hypertension, dyslipidemia, and insulin resistance. Several members of a large family of nonselective cation channels, e.g., transient receptor potential (TRP) channels, have been associated with the development of cardiovascular diseases. Thus, changes of TRP channel expression may account for the observed increased cardiov...

Introduction: Metabolic syndrome (MetS) is characterised by a combination of visceral obesity, hypertension, insulin resistance, dyslipidemia, and impaired glucose tolerance. It is a prominent risk factor for cardiovascular morbidity and mortality. The etiology of MetS is complex. The progression of MetS is influenced by genetic susceptibility and environmental factors. The aim of this study was to investigate a possible association between transient receptor potential (TRP) c...

Introduction: Autoimmune thyroid diseases result from a dysregulation of the immune system leading to an immune attack on the thyroid. Autoimmune thyroid diseases, which include Graves’ disease (GD) and Hashimoto’s thyroiditis (HT), are characterised by lymphocytic infiltration of the thyroid parenchyma. The mechanisms that trigger the autoimmune attack to the thyroid are not entirely known. The aim of this study was to investigate the possible contribution of Rho/Rh...

Objective: The aim of this study was to evaluate paraoxonase-1 (PON1) activities and its association with oxidative stress status in autoimmune thyroid disease (AITD).Materials and methods: Patients with 25 Hashimoto thyroiditis (HT) and 25 Graves’ disease (GD) and 27 healthy controls were enrolled in the study. Blood samples were obtained in euthyroid period and 3 months after the initiation of medical treatment. ...

Paraoxonase is a high-density lipoprotein-bound antioxidant enzyme that inhibits atherosclerosis. Metabolic syndrome is a combination of several metabolic abnormalities and known to be related with increased cardiovascular events. The most important component of metabolic syndrome which have impact on oxidative stress is diabetes, the most severe form of disturbed carbohydrate metabolism. The effect of metabolic syndrome on oxidative stress and paroxonase-1 (PON-1) activity ha...